Selected publications:
For a complete publication list, please see Lior Mayo's Bibliography
Tom Meyer, Dor Shimon, Sawsan Youssef, Gal Yankovitz, Adi Tessler, Tom Chernobylsky, Anat Gaoni-Yogev, Rita Perelroizen, Noga Budick-Harmelin, Lawrence Steinman, Lior Mayo. Proc Natl Acad Sci U S A. 2022 Aug 30;119(35):e2211310119.
NAD metabolism drives astrocyte proinflammatory reprogramming in central nervous system autoimmunity
Rita Perelroizen,Bar Philosof, Noga Budick-Harmelin, Tom Chernobylsky, Ariel Ron, Rotem Katzir,Dor Shimon, Adi Tessler, Orit Adir, Anat Gaoni-Yogev, Tom Meyer, Avivit Krivitsky, Nuphar Shidlovsky, Asaf Madi, Eytan Ruppin, Lior Mayo. Brain Volume 145, Issue 9, September 2022, Pages 3288–3307.
Astrocyte immunometabolic regulation of the tumour microenvironment drives glioblastoma pathogenicity.
This work was hightlited by:
Takenaka MC, Gabriely G, Rothhammer V, Mascanfroni ID, Wheeler MA, Chao CC, Gutiérrez-Vázquez C, Kenison J, Tjon EC, Barroso A, Vandeventer T, de Lima KA, Rothweiler S, Mayo L, Ghannam S, Zandee S, Healy L, Sherr D, Farez MF, Pratt A, Antel J, Reardon DA, Zhang H, Robson SC, Getz G, Weiner HL, Quintana FJ.Nat Neurosci. 2019 May;22(5):729-740.
Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39.
Benbenishty A, Gadrich M, Cottarelli A, Lubart A, Kain D, Amer M, Shaashua L, Glasner A, Erez N, Agalliu D, Mayo L, Ben-Eliyahu S, Blinder P. PLoS Biol. 2019 Mar 28; [Epub ahead of print].
Prophylactic TLR9 stimulation reduces brain metastasis through microglia activation.
Frishberg A, Peshes-Yaloz N, Cohn O, Rosentul D, Steuerman Y, Valadarsky L, Yankovitz G, Mandelboim M, Iraqi FA, Amit I, Mayo L, Bacharach E, Gat-Viks I. Nat Methods. 2019 Apr;16(4):327-332.
Cell composition analysis of bulk genomics using single-cell data.
Rubino SJ, Mayo L, Wimmer I, Siedler V, Brunner F, Hametner S, Madi A, Lanser A, Moreira T, Donnelly D, Cox L, Rezende RM, Butovsky O, Lassmann H, Weiner HL. Nat Commun. 2018 Nov 1;9(1):4578.
Acute microglia ablation induces neurodegeneration in the somatosensory system.
Steuerman Y, Cohen M, Peshes-Yaloz N, Valadarsky L,Cohn O,David E, Frishberg A, Mayo L, Bacharach E, Amit I, and Gat-Viks I. Cell Syst. 2018 Jun 27;6(6):679-691
Dissection of influenza infection in vivo by single-cell RNA sequencing
Ito Y, Ofengeim D, Najafov A, Das S, Saberi S, Li Y, Hitomi J, Zhu H, Chen H, Mayo L, Geng J, Amin P, DeWitt JP, Mookhtiar AK, Florez M,Ouchida AT, Fan JB, Pasparakis M, Kelliher MA, Ravits J, Yuan J. Science. 2016 Aug Vol. 353, Issue 6299, pp. 603-608
RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS.
Mayo L, Pires Da Cunha A, Beynon V, Yang Z, Alvarez JI, Part A, Sobel RA, Kobzik L, Lassmann H, Quintana FJ, Weiner HL. Brain. 2016 Jul;139(7):1939-1957.
IL-10 dependent Tr1 cells attenuate astrocyte activation and ameliorate chronic CNS inflammation.
This work was hightlited by:
Rothhammer V, Mascanfroni DI, Bunse L, Takenaka M, Kenison J, Mayo L, Chao C , Patel B, Yan R, Blain M, Alvarez JI, Kébir H,Anandasabapathy N, Izquierdo G, Jung S, Obholzer N, Pochet N, Clish CB, Prinz M, Prat A, Antel J, Quintana FJ. Nat Med. 2016 Jun;22(6):586-97.
Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor.
Mayo L, Trauger SA, Blain M, Nadeau M, Patel B, Alvarez JI, Mascanfroni ID, Yeste A, Kivisäkk P, Kallas K, Ellezam B, Bakshi R, Prat A, Antel JP, Weiner HL, Quintana FJ. Nat Med. 2014 Oct;20(10):1147-56.
Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation.
This work was hightlited by:
Mascanfroni ID, Yeste A, Vieira SM, Burns EJ, Patel B, Sloma I, Wu Y, Mayo L, Ben-Hamo R, Efroni S, Kuchroo VK, Robson SC, Quintana FJ. Nat Immunol. 2013 Oct;14(10):1054-63.
IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39.